- A few game titles may fail to launch or crash if the AMD Gaming Evolved overlay is enabled. A temporary workaround is to disable the AMD Gaming Evolved "In Game Overlay".
- Battlefield 4 may experience crashes when using Mantle. As a work around users are suggested to switch to DirectX 11.
- Doom some game levels may experience shimmering textures.
- The Division may hang when using Quad AMD Crossfire technology. As a workaround users are recommended to disable AMD Crossfire technology mode.
- Radeon Settings gaming profile options for Uplay applications may not take effect.
- Forza Motorsport 6: Apex may exhibit brightness flickering when using AMD FreeSync technology.
- Frame Rate Target Control gaming profiles may fail to enable for some games.
- On some AMD XConnect technology external GPU enclosures, a TDR may be observed when the dGPU is set to primary display and the laptop display is set to extended display with video playback.