* The opening of the game finds Isaac on a space station, The Sprawl, along with the Marker.
* You get to witness the start of the infection on The Sprawl
* Isaac will speak in this one.
* Isaac will interact with other NPC's in Dead Space 2.
* Isaac will continue suffering from mild dimentia as a result of his interaction with the Marker in the first game.
* Largely similar graphics but slightly updated and refined.
* More open spaces in which to fight when compared to the largely tight corridors of the first game.
* More varied weapons.
* A new "pack" animal that will use sounds to communicate what type of attack its planning. This pack animal will lure Isaac into traps by calling to him in order to lead him into an ambush by the foes you didn't see (think of the Raptors from Jurassic Park).