Alien Syndrome offers two fast-paced action-RPG modes - the dramatic and engaging single-player campaign, plus a hugely re-playable co-op multiplayer mode where up to four players can delve into the daring quest. Derived from the classic SEGA IP, Alien Syndrome for the Wii and PSP plunges players into its easy to pick up and play action-RPG gameplay, while offering depth and a wealth of features and missions to challenge all gamers.

Alien Syndrome puts players in control of the strong and enigmatic heroine - Earth Command Trooper Aileen Harding - as she battles through a wide variety of environments including onboard infested spaceships and bizarre alien planets, taking on a mixture of fearsome aliens and colossal bosses. Players can choose from a wide selection of character specialties and skills to hone their character before embarking upon their sci-fi adventure. As they progress through the engrossing campaign, protected by different types of armour and using a variety of melee and ranged weaponry, players can improve their heroine's statistics and discover powerful new abilities.

Alien Syndrome on the Wii will utilise the Wii Remote's unique gyroscopic feature by enabling players a full range of motion when slashing through enemies, unloading devastation on bosses, or running and gunning through hallways. Players will also be able to access various new game modes and mechanisms. These extra features include using the Wii controllers to craft new items, to enhance existing items and character abilities and to hack into computer systems.