- Takeuchi confirmed that that RE5 will be an authentic sequel to the series' main plot rather than a side story (as Resident Evil 4 was), and the developers are considering some kind of a conclusion to the franchise's storyline. When asked if the game will also feature some closure between Chris and Wesker's fiasco, Takeuchi said that Resident Evil 5's production is still in its early stages, so many of the details in the game are still up in the air.

- As expected, Resident Evil 5 will take advantage of the PS3's and Xbox 360's high-definition graphics. Takeuchi hopes to use real-world physics in the game so objects will react realistically when the player shoots them. Takeuchi said he is considering adopting third-party middleware for its physics engine, such as Epic Games' Unreal Engine 3.

- The gameplay of RE5 should be similar to Resident Evil 4, which adopted an over-the-shoulder third-person camera. According to Takeuchi, Resident Evil 4 stirred a lot of excitement at Capcom, since director Shinji Mikami had successfully made major changes while still keeping the essence of the series intact. Takeuchi also said that he plans to run the game at 60fps, which is double the frame rate of previous installments in the series.

- Takeuchi commented that he recently played "Half-Life 2," and he was impressed by how the game's storyline progressed without the need for the player to raise any conditional flags in the game. While he didn't say that he'll take an identical approach, he did say that RE5 is a "next-generation game" and should reflect that in its gameplay. In addition, Takeuchi emphasized he doesn't want RE5 to be too linear, where all that the user does is clear a stage, watch a cutscene, and then follow instructions to go to the next stage.