Cuphead - Cuphead is an indie run-and-gun action game with in-game visuals inspired by cartoon shows from the 1930s. Players can control the titular character Cuphead or his friend Mugman, who must traverse through strange worlds, obtain new weapons, and discover hidden secrets all while trying to repay the debt you owe to the devil. Additionally, the game heavily focuses on boss battles and utilizes traditional hand-drawn animation and backgrounds, and sports an original (and not to mention catchy) soundtrack (652 hits)
Insecticide - Crackpot Entertainment's cartoony "hard-boiled, fast-shooting detective" action/adventure (645 hits)
The Grim Adventures of Billy & Mandy - Cartoon Network game, though the PC is not among the platforms listed (566 hits)