Most of the enemies are mutated animals similar to what was seen in Nuke Dukem 3D. The pigcops make their welcome return and mutated rats, insects and more appear as well. Non-mutant enemies include a flying robot drone and a nasty lady android who wields a mean whip. Not all of the folks you mean are unfriendly. Sometimes Duke has to free some ladies from a bomb container. Of course, the ladies are extremely grateful when Duke saves them. :)