While part of the game is playable without the AGEIA PhysX processor, those that the have PhysX accelerator will have access to the complete experience with noticeable gameplay benefits. The game will automatically detect players with a PhysX card, offering them the option to progress through the single-player campaign mode that includes three "extreme PhysX" levels. PhysX users can also challenge humans and AI-enemies in four LAN-based multiplayer modes. Gamers who do not have a PhysX processor will be able to fight artificial-intelligent controlled enemies in the multiplayer "skirmish" modes, in two environments. The extreme PhysX levels were designed to spotlight physics gameplay with a purpose. For example, oil leaking from a barrel may be an indicator of its volatile nature, a spider web twitch can indicate nearby movement, lava can be psionically harnessed to deflect or smother enemies, and particle beams can be used as weapons.

Set in a futuristic, industrial war-torn atmosphere, in the campaign mode players will take each of the three characters -- Bishop, Black Ops and Guardian through five complexes: Proving Grounds, Fueling Station, Reactor Processing Core, Weapons System Control and Storage Facility. In each area, players will be presented with a set of objectives before moving on. Each character has varied abilities: Bishop can use her physics-based Psi-powers to manipulate, grab, pull, crush, etc. environmental objects to deliver deadly kills without weapons, Black Ops offers a mix of Psi and weapon powers and is the only character that can operate vehicles and Guardian, the ultimate mechanical soldier, can wield two weapons and strike his victim down with quick assault.

In the LAN modes gamers can manipulate an immense amount of objects simultaneously, control vehicles, masters Psi-powers and fight 7 friends and 16 AI-controlled enemies.