Assassin's Creed Unity in CrossFire mode will suffer from "occasional stuttering".

There's a small chance of intermittent screen tearing or corruption in Call of Duty: Advanced Warfare on high settings 4K resolution in AMD CrossFire mode,

Quad CrossFire AMD Radeon R9 295X2 may sometimes black screen when loading a game in Advanced Warfare.

AMD Radeon R9 280X/280 may experience a crash when playing Call of Duty: Advanced Warfare and a video at the same time.

CrossFire users may experience intermittent flickering in Call of Duty: Advanced Warfare menus. As a work around if this issue is seen restarting the game may cause the issue to disappear.