Call of Juarez: The Cartel has a deep and gritty storyline that begins with a fictional drug cartel bombing a U.S. law enforcement agency, devastating the building and killing hundreds of people. The attack is a surprise, leading the U.S. to believe that cartel members had somehow infiltrated federal agencies. In a last-ditch effort, the U.S. puts together a special task force to hunt down and stop the drug cartel. The task force consists of:
- Kim Evans, a gang-affiliated street kid-turned-FBI agent
- Eddie Guerra, a DEA agent with a chronic gambling habit
- Ben McCall, a brutal LAPD detective and descendant of Ray McCall from the original Call of Juarez

As the task force trio searches for the head of the cartel, they’re confronted with a variety of challenges that take them on a journey from Los Angeles, California, through Arizona and New Mexico to Juarez, Mexico. To complicate things further, Kim, Eddie and Ben each have their own personal challenges and demons to face, which makes for a complex and high-adrenaline gaming experience driven by a rich storyline evident throughout the Call of Juarez franchise.

Key features include:
 * Three player online co-op with Kim Evans, Eddie Guerra and Ben McCall
 * Gamers can play the entire campaign with each of the three characters; each character has his/her own unique story and ending
 * Huge selection of weapons including pistols, machine guns, sniper rifles, anti-air weapons and more
 * Wide variety of maps and missions including punitive raids, witness protection, undercover missions, and car chases
Additional information will be revealed soon, including details about multi-player and a twist on the three-player co-op storyline.